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Home » Publications » Radiochemical determination of cross sections of alpha-particle induced reactions on Os-192 for the production of the therapeutic radionuclide Pt-193m

Radiochemical determination of cross sections of alpha-particle induced reactions on Os-192 for the production of the therapeutic radionuclide Pt-193m

Publication date 2010
B-Phot Authors Alex Hermanne
DOI 10.1016/j.apradiso.2010.05.002
Citation
M. S. Uddin, B. Scholten, A. Hermanne, S. Sudar, H. H. Coenen, and S. M. Qaim, “Radiochemical determination of cross sections of alpha-particle induced reactions on Os-192 for the production of the therapeutic radionuclide Pt-193m,” Appl. Radiat. Isot., vol. 68, no. 10, pp. 2001–2006, 2010.
Abstract For determination of cross sections of a-particle induced reactions on 99.65% enriched Os-192, the methods for electrolytic preparation of thin samples and radiochemical separation of radioplatinum were optimized. The excitation functions of the Os-192(alpha,n)Pt-195m and Os-192(alpha,3n) Pt-193m reactions were measured from 20 to 39 MeV. The cross section of the latter reaction reaches a maximum value of about 1.5 b at an energy around 36 MeV. The results of nuclear model calculations using the codes TALYS and STAPRE agreed well with the measured data. The optimum energy range for the production of no-carrier-added Pt-193m (T-1/2=4.33 d) was found to be E alpha=40 -> 30 MeV. The thick target yield amounts to 10 MBq/mu A h and a possible batch yield of 2 GBq should be sufficient for Auger electron therapy on a wide scale. (C) 2010 Elsevier Ltd. All rights reserved.
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